Table 1.

Summary of statistically significant effects of dopamine (10 μm) on pyramidal neuron physiology

n (control/DA) Control 10 μm DA Change in DA (p < 0.05 for all)
VM (soma) 37/25 −80.4 ± 0.5 mV −78.1 ± 0.7 mV 2.5 ± 0.4 mV
VM (dendrite) 40/36 −77.9 ± 0.6 mV −74.8 ± 0.6 mV 3.0 ± 0.4 mV
RN (soma) 8 88 ± 15 MΩ 80 ± 6 MΩ −7.7 ± 2.5%
RN (dendrite) 11 55 ± 6 MΩ 46 ± 6 MΩ −16.9 ± 2.0%
Excitability (with depolarization) 21 5.2 ± 0.4 spikes 6.5 ± 0.8 spikes 20 ± 9%
Excitability (hyperpolarized) 12 5.8 ± 0.6 spikes 2.7 ± 0.9 spikes −58 ± 13%
  • Excitability was measured either during dopamine-induced depolarization (with depolarization) or with the membrane potential adjusted to control levels with a somatic DC bias current (hyperpolarized). Excitability was measured as number of spikes in response to a given somatic current injection (∼300 pA, 1 sec). Rn, Input resistance; Vm, resting membrane potential.