Table 1.

Dendritic spine size in neurons overexpressing cortactin and cortactin mutants

Cortactin mutants Spine width (μm) Spine length (μm)
Mean ± SD Mean ± SD
Control (β-gal) 1.02 ± 0.08 1.78 ± 0.18
WT 0.94 ± 0.1 2.32 ± 0.5
ΔSH3 0.86 ± 0.09 2.04 ± 0.26
ΔproSH3 0.8 ± 0.1 2.06 ± 0.29
NTAtandem 0.7 ± 0.12 2.29 ± 0.39
p value p value
β-gal : WT 0.0014 <0.0001
β-gal : ΔSH3 <0.0001 0.0013
β-gal : ΔproSH3 <0.0001 0.0024
β-gal : NTAtandem <0.0001 <0.0001
WT : ΔSH3 0.0047 0.0829
WT : ΔproSH3 0.0003 0.1604
WT : NTAtandem <0.0001 0.8043
ΔSH3 : ΔproSH3 0.1239 0.9635
ΔSH3 : NTAtandem <0.0001 0.0295
ΔproSH3 : NTAtandem 0.0120 0.0610