Table 2.

Physiological properties of synaptic transmission

Unitary IPSCsEvoked EPSCs
BrdU+ BCs (n = 16)BrdU BCs (n = 150)BrdU+BCs (n = 11)BrdU BCs (n = 96)
Latency (msec)2-a0.83  ± 0.110.77  ± 0.064.5  ± 0.625.2  ± 0.13
10–90% rise time (msec)0.66  ± 0.080.67  ± 0.030.92  ± 0.130.95  ± 0.04
Decay τ (msec)2-b4.41  ± 0.544.31  ± 0.1213.6  ± 2.713.4  ± 0.7
Peak amplitude (pA)92.1  ± 11.1101  ± 4.6142  ± 12.1149  ± 4.3
Failures (%)15.2  ± 2.416.3  ± 0.58.4  ± 1.18.6  ± 0.14
Paired-pulse responses (ratio of P2/P1)2-c0.62  ± 0.100.68  ± 0.041.36  ± 0.211.32  ± 0.04
  • F2-a Latency of unitary IPSCs was estimated from the steepest point in the rise of the BC action potential to the onset of the IPSCs. The latency of EPSCs was measured from the starting point of stimulus artifact to the onset of the EPSCs.

  • F2-b Decay time constants (τ) were measured based on monoexponential fit.

  • F2-c Paired-pulse responses (paired-pulse depression of the unitary IPSCs and paired-pulse facilitation of the EPSCs) were evoked by paired-pulse stimulation at an interval of 50 msec. Values represent mean ± SEM.