Table 1.

Demographic and neuropsychological data

MeasureControlsAD patients
Demographics1-a
 Age (years)71  ± 474  ± 9
 Education (years)15  ± 415  ± 3
 Mini mental status exam28  ± 122  ± 5*
 Mattis dementia rating scale117  ± 11
 Duration of illness (years)5  ± 3
Memory1-b
 Mattis DRS memory scale24  ± 115  ± 3*
 CVLT acquisition1-c50  ± 1021  ± 10*
 Digit span forward9  ± 28  ± 2
 Digit span backward7  ± 25  ± 2
Language/Semantic1-b
 Boston naming test28  ± 219  ± 7*
 FAS fluency47  ± 1529  ± 10*
 Semantic fluency20  ± 511  ± 4*
Visuospatial1-b
 Rey-Osterrieth figure (copy)33  ± 328  ± 10
 Line orientation25.9  ± 3.725.6  ± 2.2
Executive function1-b
 WCST (number of categories)3.8  ± 0.81.4  ± 2.1*
 Raven's matrices32  ± 328  ± 5
 Trailmaking test B (sec)72  ± 34184  ± 53*
  • Values are mean ±SD.

  • * Significantly different from controls by t test; p < 0.01. CVLT, California verbal learning test; WCST, Wisconsin card sorting test.

  • F1-a Data for subjects in the imaging study.

  • F1-b Separate control group (see Materials and Methods).

  • F1-c Standard t score.