Ultrastructural analysis of the neuromuscular junctions in the EDL muscle of transgenic and wild-type mice
| Number of postsynaptic folds | Length of postsynaptic folds (μm) | Total length of postsynapses (μm) | Area of the postsynapses (μm2) | Density of postsynaptic folds (μm/μm2) | |
|---|---|---|---|---|---|
| Young wild type (n = 15) | 16.7 ± 1.1 | 0.79 ± 0.05 | 25 ± 1.1 | 4.3 ± 0.8 | 6.9 ± 1.3 |
| Young transgenic (n = 17) | 17.5 ± 0.5 | 0.65 ± 0.04 | 27 ± 3.0 | 4.4 ± 1.4 | 6.6 ± 1.4 |
| Old wild type (n = 18) | 13.5 ± 1.4* | 0.47 ± 0.02* | 20 ± 0.5* | 2.9 ± 0.6* | 5.1 ± 0.8* |
| Old transgenic (n = 20) | 17.2 ± 1.7 | 0.78 ± 0.05 | 25 ± 0.8 | 4.7 ± 0.8 | 6.2 ± 1.1 |
Values are mean ± SEM.
↵* Indicates statistically significant difference with young wild-type, young transgenic, and old transgenic mice. The density of the postsynaptic folds was calculated as the ratio between the total length and the area of the postsynapses.