Effects of magnetic field exposure on locomotor activity
Field | Duration | Number of rats | % Circling | Mean circles | % Rearing | Mean rears |
---|---|---|---|---|---|---|
Experiments 1a and 2 | ||||||
0 T | 30 min | 22 | 5 | 1 | 91 | 3.8 ± 0.5 |
7 T | 30 min | 17 | 47 | 2.4 ± 0.6* | 59 | 2.8 ± 0.9* |
14 T | 30 min | 17 | 71 | 2.6 ± 0.4* | 0 | 0*† |
Experiment 1b | ||||||
14 T | 0 min | 6 | 0 | 0 ± 0 | 100 | 4.8 ± 0.8 |
14 T | 1 min | 6 | 0 | 0 ± 0 | 100 | 1.8 ± 0.7* |
14 T | 5 min | 8 | 50 | 5.0 ± 2.5 | 67 | 2.3 ± 0.5* |
14 T | 10 min | 14 | 57 | 2.9 ± 0.7 | 43 | 2.2 ± 0.5* |
14 T | 20 min | 8 | 63 | 2.8 ± 0.5 | 13 | 1* |
14 T | 30 min | 17 | 71 | 2.6 ± 0.4 | 0 | 0* |
Experiment 3 | ||||||
0 T Down | 30 min | 12 | 0 | 0 | 83 | 4.9 ± 1.1 |
14 T Down | 30 min | 15 | 73 | 6.1 ± 2.7 | 33 | 2.0 ± 0.3* |
14 T Up | 30 min | 13 | 77 | 8.4 ± 2.5 | 54 | 1.6 ± 0.3* |
Locomotor activity of rats after magnetic field exposure was scored for tight circling and rearing by a blind observer from videotape records. Rats were sham exposed (0 T) or exposed to 7 or 14 T magnetic fields for 0–30 min. Shown are the number of rats tested, the percentage of rats displaying circling or rearing, and the mean ± SEM number of circles or rears counted for those rats that showed any circling or rearing (i.e. non-zero means). In experiments 1a and 2, rats were exposed head-up to a 7 or 14 T magnetic field for 30 min; both exposures induced circling and suppressed rearing. In experiment 1b, rats were exposed head-up to 14 T for 0–30 min; significant circling was induced by ≥5 min of exposure, and rearing was significantly suppressed after ≥10 min of exposure. In experiment 3, rats were restrained in either the head-up or head-down orientation within a 14 T magnetic field for 30 min. Circling was induced and rearing was suppressed in both groups, but the direction of circling depended on the rats' orientation within the field (Fig. 1).