Table 1.

Clinical classification of G93A SOD1 transgene-induced disease progression

Group classificationClinical signs
PresymptomaticFull mobility and no observable difference in behavior from age-matched controls
OnsetObservation of abnormal gait or hindlimb weakness
End stageOverall muscle wasting and complete hindlimb paralysis
indexed as an inability to right themselves in a 30 sec time window; typically accompanied by paralysis of at least one front limb