Table 4.

Nrf2 upregulated genes specific to glial enriched cultures or mixed neuronal/glial cultures

GenBank accession numberGeneRFoldCVBS
Neuron increased genes
Antioxidant/reducing potential
AF090867Guanosine monophosphate reductase122.50.41330
Signal transduction
M54987Corticotropin-releasing hormone126.81.20120
M19651Fos-related antigen (Fra-1)167.41.1070
D15069Adrenomedullin1212.70.74106
Miscellaneous
M84488Vascular cell adhesion molecule-11816.50.8574
Astrocyte increased genes
Detoxification/metabolism
S83436Glutathione S-transferase, mitochondrial43.90.27341
AF041105Organic anion transporter protein411.30.4721
S56936UDP-glucuronosyltransferase, bilirubin-specific63.00.12382
X56228Rhodonase, thiosulfate sulphurtransferase87.70.651686
J02852Cytochrome P450 2A363.20.4523
Antioxidant/reducing potential
X03518γ-Glutamyl transpeptidase46.50.15149
L38615Glutathione synthetase83.90.041328
Signal transduction/apoptosis
AI228669GABA transporter protein825.20.4026
L00981Tumor necrosis factor46.70.13182
M91595Insulin-like growth factor binding protein 283.50.284228
U63740Protein kinase C-binding protein ζ 146.20.8186
AI072770Proteolipid protein610.61.10137
AI145444Neurabin, actin-binding protein43.30.1323
AF061726Calpain 383.30.24176
Inflammation
AF010464Interleukin 747.80.2632
U66322Dithiolethione-inducible gene (DIG-1)83.00.521515
M16410Tachykinin 244.50.65244
Miscellaneous
AF098301NFB42-neural F box842.60.86841
X99773Neuroserpin, serine proteinase inhibitor86.30.58187
U0902215 kDa perforational protein (PERF)897.00.6229
AF0296908-Oxoguanine-DNA-glycosylase84.70.131248
  • Genes with fold change >1.3 are listed. R, Relative rank; CV, coefficient of variation; BS, basal signal intensity from GFP-infected cultures. Data shown are from n = 2 glial-enriched cultures and n = 3 mixed cultures.