Table 2.

CZP effects on intracellularly recorded RE cell bursts

α1(H101R)Wild-type 1Wild-type 2
Control100 nmCZPControl100 nm CZPControl100 nm CZP
Bursts/sweep2.9 ± 0.21.3 ± 0.2***1.3 ± 0.40.3 ± 0.3*6.0 ± 04.3 ± 0.6*
Spikes/burst4.3 ± 0.55.6 ± 0.72.7 ± 0.43 ± 01.4 ± 0.11.4 ± 0.2
Spikes immediately after intracellular stimulation7.2 ± 0.27.3 ± 0.27.7 ± 0.28.0 ± 05 ± 04.8 ± 0.3
  • CZP reduces the number of bursts, but not spikes per burst, in intracellular recordings from RE cells. The number of bursts per evoked oscillation, the number of spikes per burst, and the number of spikes in the 50–100 msec immediately after internal capsule stimulation are shown for each of three intracellularly recorded RE cells. In every case, the number of bursts per oscillation is significantly reduced, whereas the number of spikes per burst and the number of spikes immediately after internal capsule stimulation remain unchanged. *p < 0.05; ***p < 0.001.