OEA hydrolytic activities in brain regions of FAAH (+/+) and (−/−) mice
| Brain region | FAAH activity (pmol/min/mg protein), mean ± SEM | |
|---|---|---|
| +/+ | −/− | |
| Hippocampus | 57.93 ± 1.84 | 0.38 ± 0.16 |
| Cortex | 45.86 ± 5.09 | 0.98 ± 0.44 |
| Cerebellum | 28.4 ± 1.1 | 0.78 ± 0.11 |
Rates of hydrolysis of OEA were significantly reduced in FAAH (−/−) mice compared with FAAH (+/+) mice in all three brain regions tested (p < 0.001; unpaired t test; n = 3 per group).