Table 1.

Effect of β-PMTX on activation parameters of sodium currents

Control β-PMTX np value
Wild-type Purkinje V½ (mV) −39 ± 1 −35 ± 1 10 0.02
k (mV) 4.5 ± 0.7 5.9 ± 0.7 0.02
Gmax (nS) 61 ± 5 54 ± 3 0.01
Wild-type CA3 V½ (mV) −35 ± 2 −38 ± 2 5 0.04
k (mV) 4.7 ± 0.4 5.2 ± 0.4 0.4
Gmax (nS) 34 ± 9 30 ± 8 0.1
med Purkinje V½ (mV) −39 ± 2 −42 ± 2 7 0.03
k (mV) 6.5 ± 0.3 7.8 ± 0.6 0.03
Gmax (nS) 25 ± 4.3 23 ± 4.3 0.15