Table 2.

Summary of measured values in vivo, in vitro, and the model

In VivoIn Vitro Model
Stimulus 0-60 Hz 0-60 Hz 0-20 Hz 40-60 Hz 0-60 Hz 0-60 Hz
Condition Control TTX ADM PDM
Firing rate (spikes/sec) 22 ± 12.9 18 ± 4 16 ± 3 16 ± 2 18 18 32 Hz 33 Hz
Burst fraction 0.49 ± 0.16 0.22 ± 0.12 0.32 ± 0.19 0.008 ± 0.005 0.16 0.08 0.24 0.064
n 33 24 6 6 3 3 NA NA
All spikes
    Clow 0.24 ± 0.12 0.47 ± 0.08 0.51 ± 0.09 NA 0.5 0.5 0.67 0.72
    Chigh 0.10 ± 0.10 0.31 ± 0.08 NA 0.60 ± 0.10 0.32 0.34 0.38 0.39
Burst events
    Clow 0.13 ± 0.08 0.13 ± 0.07 0.15 ± 0.07 NA 0.19 0.12 0.27 0.14
    Chigh 0.03 ± 0.03 0.04 ± 0.02 NA 0.02 ± 0.01 0.05 0.03 0.16 0.07
Isolated spikes
    Clow 0.08 ± 0.04 0.28 ± 0.08 0.42 ± 0.05 NA 0.25 0.33 0.19 0.47
    Chigh 0.08 ± 0.08 0.30 ± 0.14 NA 0.54 ± 0.13 0.29 0.33 0.25 0.319
BTA
    Plow 0.041 ± 0.055 0.20 ± 0.06
    Phigh 0.009 ± 0.054 0.05 ± 0.01
STA
    Plow 0.021 ± 0.054 0.06 ± 0.03
    Phigh 0.010 ± 0.016 0.04 ± 0.01
  • Stimuli were Gaussian noise ranging from 0 to 60, 0 to 20, and 40 to 60 Hz and were applied in vivo, in vitro, or in the model as indicated. The mean firing rate and burst fraction during stimulation are reported. In some cases, the stimulus was applied in the presence or absence of TTX in vitro or in the presence of active dendritic backpropagation (ADM) or the absence of backpropagation (PDM). Coherence between the stimuli and the full spike trains, burst trains, and isolated spike trains were measured. Clow and Chigh correspond to the mean values of the coherence measured in the 0-20 and 40-60 Hz ranges, respectively. The power spectrums of the BTA and STA were obtained. Plow and Phigh correspond to the mean power measured in the 0-20 and 40-60 Hz ranges, respectively. NA, Not applicable.