Table 1.

Cell parameters for different transgenic mice

Genotype Cap, pF ± SEM (n) Rinp, MΩ ± SEM (n) τ ImAHP, msec ± SEM (n) T1/2 IsAHP, msec ± SEM (n) τ IsAHP, sec ± SEM (n)
WT 120.1 ± 15.4 (15) 257.6 ± 21.7 (15) 192.4 ± 10.9 (15) 183.0 ± 12.4 (3) 2.9 ± 0.2 (7)
SK2 Δ/Δ[ρ] 130.5 ± 14.0 (15) 270.0 ± 25.5 (15) 244.2 ± 98.9 (3) 3.2 ± 0.2 (9)
SK1 Δ/Δ[ρ] 123.0 ± 20.7 (8) 219.5 ± 18.1 (8) 200.2 ± 26.0 (7) 163.7 ± 52.9 (2) 3.3 ± 0.3 (5)
SK3 T/T (dox) 137.5 ± 8.5 (12) 232.5 ± 12.6 (13) 197.0 ± 15.7 (11) 135.2 ± 11.9 (2) 2.7 ± 0.1 (8)
  • Data presented as mean ± SEM; Cap, cell capacitance; Rinp, cell input resistance; τ ImAHP, decay time constant of apamin-sensitive component of IAHP; T1/2 IsAHP, time to half peak of IsAHP; τIsAHP, time constant of decay of IsAHP in presence of apamin.