Anatomical and physiological measures of autonomic function in passive transfer EAAN using rabbit IgG
| Control | EAANa | Recoveryb | |
|---|---|---|---|
| Initial body weight (gm; day 0) | 25.1 ± 0.4 (29) | 24.8 ± 0.5 (42) | |
| Weight change (gm; day 3)c | −0.88 ± 0.25 (28) | −3.26 ± 0.32 (39)* | |
| Resting heart rate (bpm) | 749 ± 3 (21) | 732 ± 8 (23) | 759 ± 4 (5) |
| rMSSD (μsec) | 836 ± 53 (21) | 542 ± 34 (23)* | 728 ± 70 (5) |
| Gl transit (percentage of small bowel) | 53.3 ± 4.1% (21) | 30.8 ± 2.4% (22)* | 53.4 ± 9.3% (5) |
| Bladder weight (mg) | 79.0 ± 10.4 (23) | 246.6 ± 23.2 (31)* | 49.6 ± 14.6 (5) |
| Stomach weight (mg) | 305.4 ± 13.9 (21) | 443.9 ± 20.6 (24)* | 436.4 ± 11.6 (5)* |
| Rest NE (ng/ml) | 3.69 ± 0.96 (9) | 4.89 ± 1.30 (10) | |
| Stress NE (ng/ml) | 19.01 ± 1.33 (22) | 5.18 ± 0.76 (24)* | 11.24 ± 2.25 (5) |
All data are mean ± SEM (number of mice). rMSSD, Root mean square of successive differences in heart period, a measure of heart-rate variability; NE, plasma norepinephrine concentration. *p<0.0001 compared with control mice (Wilcoxon rank sum test).
↵ a Except for body weight, data are from experimental days 2-7.
↵ b Data are from EAAN mice examined on experimental days 14-27.
↵ c Data are from all mice except those killed before experimental day 3.