Table 1.

Differentially expressed genes in sAPP α-treated organotypic hippocampal slice cultures

Classification Gene name FC Rank
Amyloid sequestration Transthyretin 8.94 ± 4.49 12
Apoptosis Apoptosis inhibitor 6 2.09 ± 1.12 10
Calcium binding Calmodulin-like 4 1.75 ± 0.42 12
Cell cycle Cyclin D2 4.22 ± 0.88 11
Cyclin-dependent kinase 4 1.26 ± 0.05 10
Detoxification Glutathione S-transferase, α4 3.52 ± 1.11 14
Glutathione S-transferase, μ5 1.38 ± 0.40 9
Peroxiredoxin 2 1.19 ± 0.31 10
Extracellular matrix and tissue remodeling Elastin 1.66 ± 1.22 9
Chondroitin sulfate proteoglycan 2 1.62 ± 0.21 11
Glycolysis Phosphofructokinase, platelet 1.32 ± 0.06 12
Galactokinase 1 1.28 ± 0.30 10
Growth Insulin-like growth factor 2 2.58 ± 0.42 14
Insulin-like growth factor binding protein 2 1.53 ± 0.08 14
Immune related Lymphocyte antigen 6 complex, locus A 1.90 ± 0.97 12
Intercellular adhesion molecule 2 1.71 ± 0.73 9
Ion channel FXYD domain-containing ion transport regulator 1 1.20 ± 0.30 10
Peroxisome (fatty acid transport) ATP-binding cassette, subfamily D, member 3 1.35 ± 0.12 9
Prostaglandin synthesis Prostaglandin D2 synthase (brain) 1.97 ± 0.53 12
Protein catabolism Proteasome (prosome, macropain) 28 subunit, α 2.67 ± 0.73 10
Praja 1, RING-H2 motif containing 1.20 ± 0.03 9
Receptor Cytokine receptor-like factor 1 1.54 ± 0.45 9
Receptor (calcitonin) activity modifying protein 1 1.27 ± 0.06 9
Retionic acid binding Cellular retinoic acid binding protein II 2.37 ± 0.29 16
Retinol binding protein 1, cellular 1.69 ± 0.15 16
Miscellaneous Eyes absent 4 homolog (Drosophila) 19.26 ± 8.88 11
H19 fetal liver mRNA 1.95 ± 0.23 17
Ectonucleotide pyrophosphatase/phosphodiesterase 2 1.88 ± 0.82 11
Phosphatidic acid phosphatase 2a 1.83 ± 0.78 10
Heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (Saccharomyces cerevisiae) 1.34 ± 0.35 10
Topoisomerase (DNA) II α 1.34 ± 0.96 10
Neuronal protein 15.6 1.33 ± 0.05 10
Ribosomal protein L8 1.32 ± 0.08 11
Ena-vasodilator stimulated phosphoprotein 1.28 ± 0.35 10
Thymus cell antigen 1, θ 1.27 ± 0.32 11
ADP-ribosylation-like factor 6 interacting protein 5 1.25 ± 0.04 14
STIP1 homology and U-box containing protein 1 1.19 ± 0.05 9
ESTs AW060684 4.54 ± 1.78 9
AW121164 2.54 ± 0.86 9
AW121336 2.50 ± 0.34 9
AW060956 1.35 ± 0.11 9
AW120814 1.32 ± 0.11 9
AW124069 1.26 ± 0.34 9
AW048976 1.24 ± 0.08 10
AI226264 1.21 ± 0.03 10
  • Rank is based on the p value for each comparison (3 × 3). Rank values ranging from 9 to 18 indicate significantly increased gene expression. FC is expressed as mean ± SEM.