Receiving negative feedback minus control feedback in both matched control and PD patient groups
| Control subjects | PD patients | ||||||
|---|---|---|---|---|---|---|---|
| Anatomical area | X,Y,Z | T statistic | Cluster | X,Y,Z | T statistic | Cluster | |
| Positive peaks | |||||||
| DLPFC (46, 9/46) | L | −42,32,28 | 3.70 | 1168 | −52,36,18 | 5.33 | 1692 |
| R | 48,26,32 | 3.85* | 256 | ||||
| VLPFC (47/12) | L | −34,22,4 | 3.87* | 352 | |||
| R | 32,22,4 | 5.27 | 560 | ||||
| Anterior CC (32 rostral) | L | −8,20,46 | 4.82 | 2512 | −6,30,42 | 4.43 | 536 |
| R | 6,28,46 | 5.29 | 2184 | 6,26,40 | 3.52* | sc | |
| Posterior PFC (6,8,44) | L | −50,18,36 | 4.9 | 2952 | |||
| Lateral PMC (6 rostral) | L | −44,8,36 | 5.41 | 2752 | −28,10,52 | 4.7 | 1136 |
| R | 44,8,36 | 4.52 | 1288 | 34,14,56 | 4.19* | 136 | |
| PMC (6 caudal) | R | 24,2,48 | 3.61* | 160 | |||
| PPC (40) | L | −44, −50,42 | 4.12 | 552 | −36, −54,42 | 5.18 | 3120 |
| R | 40, −42,42 | 3.66* | 280 | ||||
| PPC (7) | L | −38, −76,40 | 5.53 | 3360 | |||
| R | 28, −58,54 | 4.83 | 1600 | 34, −64,50 | 3.71* | 152 | |
| Prestriate cortex (19) | L | −28, −66,38 | 5.41 | 3024 | −10, −84, −4 | 6.53 | >5000 |
| −26, −94,2 | 4.69 | 2112 | |||||
| R | 20, −76,40 | 3.73* | 120 | 8, −76,6 | 6.05 | >5000 | |
| Caudate/thalamus | L | −12, −2,2 | 4.76 | 856 | |||
| −10, −6,2 | 3.91 | sc | |||||
| Negative peaks | |||||||
| Frontopolar cortex (10) | R | 2,58,12 | 3.96* | 136 | |||
| Insula | R | 34,8,12 | 4.88 | 1206 | |||
| Lateral PMC (6 caudal) | L | −40,0,12 | 4.73 | 1448 | |||
| R | 52,2,10 | 5.2 | 1396 | ||||
| Motor CC (24) | L | −2, −12,52 | 5.04 | 3192 | |||
| R | 2, −12,62 | 5.75 | 4304 | ||||
| 10, −6,38 | 3.6 | 504 | |||||
| Motor cortex (4) | L | −34, −22,56 | 4.04 | 616 | −44, −22,58 | 5.75 | 2560 |
| PPC (40) | L | −62, −24,20 | 4.16 | 776 | |||
| R | 58, −24,26 | 5.24 | 2800 | 44, −32,24 | 4.63 | 3168 | |
| MTC (21) | R | 62, −44,4 | 4.72 | 792 | |||
| Posterior CC (23) | R | 6, −48,28 | 4.50 | 1752 | |||
| Anterior insular cortex | L | −30,4,14 | 4.72 | 1816 | |||
| Posterior insular cortex | R | 32, −16,16 | 4.32 | 920 | |||
L, Left; R, right; DL, dorsolateral; VL, ventrolateral; CC, cingulate cortex; MTC, middle temporal cortex; OFC, orbitofrontal cortex; PMC, premotor cortex; PPC, posterior parietal cortex. When no asterisk is indicated, p < 0.05 corrected; * p < 0.001 uncorrected. Cluster sizes are reported in mm3. scindicates that the peak is part of the same cluster as the peak listed immediately above in the table and that its size, therefore, is included in the preceding reported volume. The numbers in parentheses refer to architectonic areas.