Table 1.

Sex chromosome karyotypes in the adult cerebral cortex

Number of nuclei observed (fold change relative to WTa) Prevalence of aneuploid nuclei (fold change relative to WTa)
Mutant XY OY XXY XYY XO
Atm−/−b 840 1 (0.4) 5 (2.7) 20 (2.2) 44 (1.1) 7.7% (1.3)
Xrcc5−/−c 603 1 (1.3) 4 (1.3) 0 (e) 16 (0.4) 3.4% (0.5)
Trp53−/−d 904 4 (0.3) 2 (0.3) 1 (0.4) 7 (0.1) 1.5% (0.2)
  • a Fold change is calculated by dividing the percentage of aneuploid nuclei observed in mutant mice by the percentage of aneuploid nuclei observed in WT cohorts. A fold change < 1 indicates a relative increase.

  • b Fisher's exact test versus WT cohorts (see Materials and Methods), p < 0.05.

  • c Fisher's exact test versus WT cohorts, p < 0.001.

  • d Fisher's exact test versus WT cohorts, p < 0.0001.

  • e Fold change cannot be calculated for zero observations relative to one observation.