Sex chromosome karyotypes in the adult cerebral cortex
| Number of nuclei observed (fold change relative to WTa) | Prevalence of aneuploid nuclei (fold change relative to WTa) | |||||
|---|---|---|---|---|---|---|
| Mutant | XY | OY | XXY | XYY | XO | |
| Atm−/−b | 840 | 1 (0.4) | 5 (2.7) | 20 (2.2) | 44 (1.1) | 7.7% (1.3) |
| Xrcc5−/−c | 603 | 1 (1.3) | 4 (1.3) | 0 (e) | 16 (0.4) | 3.4% (0.5) |
| Trp53−/−d | 904 | 4 (0.3) | 2 (0.3) | 1 (0.4) | 7 (0.1) | 1.5% (0.2) |
↵ a Fold change is calculated by dividing the percentage of aneuploid nuclei observed in mutant mice by the percentage of aneuploid nuclei observed in WT cohorts. A fold change < 1 indicates a relative increase.
↵ b Fisher's exact test versus WT cohorts (see Materials and Methods), p < 0.05.
↵ c Fisher's exact test versus WT cohorts, p < 0.001.
↵ d Fisher's exact test versus WT cohorts, p < 0.0001.
↵ e Fold change cannot be calculated for zero observations relative to one observation.