Table 1.

Effects of ISO on mIPSCs from hippocampal Swiss White, WT, and α5−/− mice

Type Group n Frequency (Hz) Amplitude (pA) Rise (msec) Q (pA·msec) Decay (msec)
Control 5 3.2 ± 1.4 33.3 ± 4.1 1.9 ± 0.2 655.3 ± 67.4 17.6 ± 1.5
ISO 25 μM 5 2.6 ± 1.1 31.7 ± 1.9 2.0 ± 0.1 658.6 ± 55.2 19.7 ± 2.4
Swiss White ISO 250 μM 5 0.9 ± 0.2* 37.2 ± 4.2 2.4 ± 0.2* 1465.2 ± 246.6* 57.8 ± 11.8*
Control 5 2.0 ± 1.1 28.5 ± 3.5 1.9 ± 0.3 537.7 ± 71.9 16.7 ± 2.1
ISO 25 μM 5 1.8 ± 1.0 27.0 ± 2.3 2.2 ± 0.3 583.7 ± 24.7 19.1 ± 2.8
WT ISO 250 μM 5 1.0 ± 0.5* 31.5 ± 4.7 2.7 ± 0.3* 1017.4 ± 237.4* 42.3 ± 3.9*
Control 6 2.3 ± 1.2 30.3 ± 2.8 1.8 ± 0.2 677.9 ± 58.3 23.8 ± 2.9
ISO 25 μM 6 2.3 ± 1.1 29.7 ± 4.2 1.9 ± 0.2 652.2 ± 81.2 22.6 ± 2.7
α5−/− ISO 250 μM 6 1.3 ± 0.5* 31.1 ± 4.6 2.4 ± 0.1* 1130.8 ± 180.5* 48.1 ± 3.8*
  • * p < 0.05 versus control.