Table 1.

Desensitization time constants

Receptor Residues exchanged τDES (msec)
GluR1i - 3.8 ± 0.05 (12)
GluR1o - 4.2 ± 0.2 (10)
GluR2i - 5.8 ± 0.2 (20)
GluR2o - 1.6 ± 0.1 (16)
GluR3i - 3.6 ± 0.3 (10)
GluR3o - 1.5 ± 0.1 (7)
GluR4i - 5.1 ± 0.4 (16)
GluR4o - 0.9 ± 0.03 (14)
GluR2io,i,i T765N, P766A 2.7 ± 0.1 (15)
GluR2ii,o,i S775N 4.7 ± 0.2 (16)
GluR2iV779L V779L 5.1 ± 0.2 (13)
GluR2ii,i,o A796S, K797G, D798G, S799G, G800D 5.8 ± 0.2 (23)
GluR2io,o,i T765N, P766A, S775N 1.8 ± 0.1 (18)
GluR2iT765N T765N 3.6 ± 0.1 (18)
GluR2iP766A P766A 3.6 ± 0.2 (15)
GluR2io,i,o T765N, P766A, K797G, D798G, S799G, G800D 2.5 ± 0.1 (18)
GluR2io,i,V779L,i T765N, P766A, V779L 2.1 ± 0.2 (15)
GluR2oi,o,o N765T, A766P 4.2 ± 0.2 (15)
GluR2oo,i,o N775S 2.3 ± 0.1 (13)
GluR2oi,i,o N765T, A766P, N775S 5.7 ± 0.2 (20)
  • τDES was estimated from single exponential fits as described in Materials and Methods. Numbers in parentheses indicate the number of cells.