Table 1.

Effects of S1627 on various kinases

Kinase Percentage inhibition at 20 μm S1627 IC50m) of S1627 Reference compound IC50m) of reference compound
Casein kinase II 25 Hypericin 7
Cdk1 (cyclin-dependent protein kinase) 23 Roscovitine 2.1
CaMKII (Ca2+-calmodulin-dependent kinase) 86 14.6 Staurosporine 0.007
Erk-2 (p42 MAPK) 0 Staurosporine 7.4
p38β MAPK 11 SB-202190 0.034
MEK1 (MAP kinase kinase) 84 18.2 Staurosporine 0.03
Protein kinase A (stimulated) 21 H89 0.23
PKCα 0 Staurosporine 0.037
EGF receptor tyrosine kinase 16 PD 153035 0.005
Abl (nonreceptor tyrosine kinase) 5 Staurosporine 0.04
Src (nonreceptor tyrosine kinase) 103 2.18 Staurosporine 0.04
ZAP70 (Src family tyrosine kinase) 93 2.43 Staurosporine 0.016
  • Kinase activity was determined by Cerep (Paris, France). MAPK, MAP kinase; EGF, epidermal growth factor.