Parameters used in the model
| Parameter | Definition | Value | Reference |
|---|---|---|---|
| R | Gas constant | 8.315 JK-1 mol-1 | |
| T | Absolute temperature | 303 K | |
| F | Faraday constant | 9.65 104 C mol-1 | |
| e | Elementary charge | 1.60 10-19 C | |
| NA | Avogadro number | 6.02 1023 mol-1 | |
| Vsp | Spine volume | 0.08 fL | Harris and Stevens (1989) |
| Pca/PM | NMDA-R permeability of Ca2+/Permeability of monovalent ions | 3.6 | Spruston et al. (1995) |
| γ | Conductance of monovalent ions | 46 pS | Spruston et al. (1995) |
| [M+] | Concentration of monovalent ions | 130 mm | |
| [Ca2+]ex | External [Ca2+] | 2.0 mm | |
| kex | Ca2+ clearance rate constant in the absence of Ca2+ buffer | 1.6 msec-1 | Sabatini et al. (2002) |
| Ki | Endogenous buffer capacity | 20 | Sabatini et al. (2002) |
| Kd | Dissociation constant of dye | 0.5 μm for Fluo-4 | Oertner et al. (2002) |
| 9.7 μm for Fluo-4FF | Molecular Probes Handbook of Fluorescent Probes and Research Products | ||
| [dye]Total | Total dye added | 150 μm for Fluo-4 | |
| 500 μm for Fluo-4FF | |||
| Po | Open probability | 0.3 | Dzubay and Jahr (1996) |
| τPoisson | Average open time | 100 msec | Figure 2E |