Table 1.

The electrophysiological properties of AMPA receptors without γ2 and γ2 mutants

Construct n Peak current (pA) Steady state/peak (%) τdes (ms)
GluR1 23 599 ± 130 0.6 ± 0.2 3.0 ± 0.2
GluR1 plus γ2 24 1061 ± 194* 9 ± 1** 7.4 ± 0.3**
GluR1 plus γ2ΔPDZ 9 1183 ± 559 9 ± 2** 8.3 ± 1.1**
GluR1 plus γ2Δ(265-323) 4 939 ± 447 11 ± 3** 10.0 ± 1.5**
GluR1 plus γ2Δ(244-283) 5 515 ± 195 14 ± 4** 10.0 ± 2.0**
GluR2 12 677 ± 279 4 ± 1 9.1 ± 0.4
GluR2 plus γ2 11 1630 ± 422 27 ± 4** 19.2 ± 1.3**
GluR2 plus γ2ΔPDZ 4 350 ± 139 14 ± 2** 17.8 ± 1.5**
  • *p < 0.05; **p < 0.001 compared with AMPA receptor expressed without γ2.