Amplitude (pA) | Frequency (Hz) | τ_{fast} (τ_{0}) | τ_{slow} (τ_{1}) | A_{fast} (A_{0}) | A_{slow} (A_{1}) | A_{fast}/A_{slow}(A_{0}/A_{1}) | n | ||
---|---|---|---|---|---|---|---|---|---|
mEPSC | |||||||||
Control | 8.0 ± 0.6 | 0.1 ± 0.01 | n.e. | 100.9 ± 9.6 | 0 | 14.8 ± 1.4 | 0 | 11 | 17 |
5.7 ± 0.3 | 106.1 ± 13.1 | 2.4 ± 1.0 | 14.6 ± 1.2 | 0.16 ± 1.2 | 6 | ||||
Shank3 | 18.9 ± 3.3^{**} | 2.5 ± 0.2^{**} | 4.8 ± 2.5 | 45.5 ± 8.7^{**} | 10.0 ± 1.7^{**} | 16.3 ± 1.2 | 0.61 ± 2.0^{**} | 19 | |
sEPSC | |||||||||
Control | 16.7 ± 3.4 | 1.1 ± 0.2 | n.d. | n.d. | n.d. | n.d. | n.d. | 19 | |
Shank3 | 27.5 ± 2.0^{*} | 5.8 ± 0.3^{*} | n.d. | n.d. | n.d. | n.d. | n.d. | 12 |
Each value is the mean ± SEM obtained from the indicated number of neurons (n). The recorded mEPSCs and sEPSCs were best fitted with either single- or double-exponential relationships of the following type: I = A_{0} exp(−t/τ_{0}) + A_{1} exp(−t/τ_{1}) + C. Note that for the mEPSC studies, over 17 control neurons, 11 displayed mEPSCs with slow time constant (τ_{1}) single-exponential decay, and only six displayed mEPSCs with double (τ_{0} and τ_{1})-exponential decay. n.e., Nonexisting fast decay component; n. d., not determined. ^{*}p ≤0.05; ^{**}p ≤ 0.01.