Table 2.

Effects of Shank3 transfection on mEPSC and sEPSC

Amplitude (pA) Frequency (Hz) τfast0) τslow1) Afast (A0) Aslow (A1) Afast/Aslow(A0/A1) n
mEPSC
Control 8.0 ± 0.6 0.1 ± 0.01 n.e. 100.9 ± 9.6 0 14.8 ± 1.4 0 11 17
5.7 ± 0.3 106.1 ± 13.1 2.4 ± 1.0 14.6 ± 1.2 0.16 ± 1.2 6
Shank3 18.9 ± 3.3** 2.5 ± 0.2** 4.8 ± 2.5 45.5 ± 8.7** 10.0 ± 1.7** 16.3 ± 1.2 0.61 ± 2.0** 19
sEPSC
Control 16.7 ± 3.4 1.1 ± 0.2 n.d. n.d. n.d. n.d. n.d. 19
Shank3 27.5 ± 2.0* 5.8 ± 0.3* n.d. n.d. n.d. n.d. n.d. 12
  • Each value is the mean ± SEM obtained from the indicated number of neurons (n). The recorded mEPSCs and sEPSCs were best fitted with either single- or double-exponential relationships of the following type: I = A0 exp(−t0) + A1 exp(−t1) + C. Note that for the mEPSC studies, over 17 control neurons, 11 displayed mEPSCs with slow time constant (τ1) single-exponential decay, and only six displayed mEPSCs with double (τ0 and τ1)-exponential decay. n.e., Nonexisting fast decay component; n. d., not determined. *p ≤0.05; **p ≤ 0.01.