Table 1.

Effect of aminopyridines on caffeine-induced attacks

Pretreatment 5 mg/kg caffeine 15 mg/kg caffeine
Percentage of attacks Duration (min) (mean ± SEM) Severity (scale of 1-5) Percentage of attacks Duration (min) (mean ± SEM) Severity (scale of 1-5)
Saline 81 71 ± 3(68/84) 3.4 ± 0.1 98 92 ± 3(82/84) 3.2 ± 0.1
2-AP (5 mg/kg) 94 79 ± 8(16/17) 3.3 ± 0.1 88 86 ± 8(14/16) 3.1 ± 0.1
3-AP (10 mg/kg) 61 65 ± 11(11/18) 3.1 ± 0.1 94 96 ± 6(17/18) 3.2 ± 0.1
4-AP (1 mg/kg) 40** 63 ± 18(6/15) 3.3 ± 0.1 83* 83 ± 8(15/18) 3.1 ± 0.1
3,4-DiAP (5 mg/kg) 6**** 60(1/18) 3.0 17**** 107 ± 9(3/18) 3.5 ± 0.4
4-DMAP (20 mg/kg) 41** 29 ± 9*(7/17) 3.0 ± 0.1 83* 57 ± 7**(15/18) 3.1 ± 0.1
  • Values in parentheses represent the number of mice with attacks/the number of mice tested. Each drug was tested concomitantly with a saline pretreatment control group. Asterisks denote significant differences from saline pretreatment as determined by logistic regression for percentage of attacks and ANOVA for duration (*p < 0.05; **p < 0.01; ****p < 0.0001). Severity data are expressed as means ± SEM for ease of presentation.