Table 2.

Single-channel parameters of AITC-induced activation (in the absence of external Ca2+), Ca2+-induced potentiation, and Ca2+-induced inactivation obtained from outside-out patches at a holding potential of −80 mV

Phase Popen Burst duration (ms) Open time (ms) Close time (ms) Amplitude (pA)
Ca2+-free activation 0.17 ± 0.11 11.7 ± 24.4 4.4 ± 5.9 78.5 ± 177 5.7 ± 0.4
Ca2+-induced potentiation 0.51 ± 0.30 94.2 ± 133 6.1 ± 8.9 7.4 ± 25.6 3.1 ± 0.4
Ca2+-induced inactivation 0.02 ± 0.01 4.1 ± 1.3 ND ND 3.1 ± 0.4
  • Data show mean ± SD estimated from 1117 events pooled from four separate experiments. ND, Not determined.