Summary of the disease or damage responses and retinal localization(s) for transcripts from 12 genes
| Gene | Induction with light exposure | Induction with retinal detachment | Induction in one or more genetic retinopathies | Cell type in which the RNA is induced |
|---|---|---|---|---|
| Cd44 | + | − | + | Muller cells |
| Cp | + | + | − | Muller cells, astrocytes |
| Ednrb | + | − | − | Muller cells |
| Edn2 | + | + | + | Photoreceptors |
| Fgf2 | + | +/− | + | Photoreceptors |
| Lcn2 | + | + | + | Muller cells, astrocytes |
| Lgals3 | + | − | +/− | Muller cells |
| Myo10 | + | ND | + | ND |
| Rbp1 | + | − | + | Muller cells |
| Serpina3n | + | + | + | Muller cells, astrocytes, RPE |
| Socs3 | + | ND | + | ND |
| Spp1. | + | − | − | Microglia, macrophages |
+/−, Weak induction; ND, not determined. The assignments of cell type are based on transcript localization in differential interference contrast images; they have not been confirmed by double labeling with cell type-specific markers. In the pigmented C57BL/6 mouse used for retinal detachment, any hybridization signals in the RPE would be obscured by melanin.