4 months of age | 6 months of age | |||||
---|---|---|---|---|---|---|
Region | WT (6) | Fmr1 null (8) | WT (6) | Fmr1 null (6) | F(1,22) age | F(1,22) genotype |
Thalamus | ||||||
Lateral dorsal nucleus | 4.4 ± 0.3 | 5.0 ± 0.2 | 3.4 ± 0.2 | 3.9 ± 0.3 | 16.89*** | 5.10* |
Medial dorsal nucleus | 4.2 ± 0.3 | 5.0 ± 0.2 | 3.4 ± 0.2 | 4.1 ± 0.3 | 11.17** | 6.97* |
Ventral medial posterior nucleus | 4.6 ± 0.3 | 5.4 ± 0.2 | 3.7 ± 0.2 | 4.3 ± 0.3 | 13.47** | 5.84* |
Anterior dorsal nucleus | 8.5 ± 0.4 | 9.4 ± 0.3 | 6.9 ± 0.6 | 7.6 ± 0.6 | 13.88** | 2.77 |
Anterior ventral nucleus | 5.8 ± 0.2 | 6.5 ± 0.2 | 4.6 ± 0.3 | 5.0 ± 0.4 | 23.86*** | 3.45 |
Medial habenula | 8.2 ± 0.6 | 9.7 ± 0.2 | 6.7 ± 0.4 | 7.6 ± 0.4 | 22.16*** | 10.01** |
Lateral habenula | 5.7 ± 0.4 | 6.7 ± 0.2† | 4.6 ± 0.2 | 5.2 ± 0.4 | 18.72*** | 8.00** |
Hypothalamus | ||||||
Supraoptic nucleus | 8.6 ± 0.6 | 9.7 ± 0.4 | 6.5 ± 0.4 | 8.7 ± 0.8† | 7.85* | 8.78** |
Paraventricular nucleus | 8.3 ± 0.5 | 9.8 ± 0.4† | 6.2 ± 0.4 | 7.7 ± 0.6 | 17.33** | 9.05** |
Lateral magnocellular | 9.2 ± 0.4 | 10.2 ± 0.4 | 6.6 ± 0.6 | 7.9 ± 0.8 | 20.45*** | 4.40* |
Ventral | 7.5 ± 0.4 | 8.4 ± 0.3 | 4.7 ± 0.4 | 5.6 ± 0.5 | 46.64*** | 5.03* |
Medial parvicellular | 6.3 ± 0.3 | 6.9 ± 0.3 | 4.1 ± 0.4 | 4.6 ± 0.4 | 42.45*** | 2.65 |
Suprachiasmatic nucleus | 4.9 ± 0.3 | 5.8 ± 0.2† | 3.8 ± 0.3 | 4.8 ± 0.4 | 11.95** | 9.00** |
Medial preoptic area | 5.6 ± 0.3 | 6.4 ± 0.3 | 3.2 ± 0.2 | 3.1 ± 0.3 | 95.28*** | 1.48 |
Anterior area | 3.9 ± 0.1 | 4.3 ± 0.2 | 3.0 ± 0.2 | 3.4 ± 0.4 | 16.05*** | 3.84 |
Lateral area | 3.9 ± 0.2 | 4.5 ± 0.1† | 3.0 ± 0.3 | 4.1 ± 0.3†† | 6.92* | 12.34** |
Lateral anterior nucleus | 3.9 ± 0.2 | 4.4 ± 0.2 | 3.2 ± 0.2 | 3.7 ± 0.4 | 7.78* | 3.60 |
Periventricular nucleus | 5.3 ± 0.3 | 6.0 ± 0.3 | 3.8 ± 0.3 | 5.0 ± 0.5† | 12.73** | 8.80** |
Medial preoptic nucleus | 4.4 ± 0.2 | 4.8 ± 0.1 | 3.8 ± 0.2 | 3.9 ± 0.4 | 8.71** | 1.24 |
Lateral preoptic nucleus | 3.9 ± 0.2 | 4.2 ± 0.1 | 3.1 ± 0.2 | 3.5 ± 0.4 | 11.22** | 3.16 |
Arcuate nucleus | 6.2 ± 0.2 | 6.8 ± 0.3 | 5.0 ± 0.5 | 6.6 ± 0.6† | 2.90 | 6.64* |
Median eminence | 3.7 ± 1.2 | 5.2 ± 1.2 | 4.1 ± 0.4 | 5.8 ± 0.4 | 0.28 | 2.80 |
Dorsomedial nucleus | 4.6 ± 0.2 | 4.7 ± 0.2 | 3.7 ± 0.2 | 4.1 ± 0.4 | 7.16* | 0.66 |
Ventromedial nucleus | 5.0 ± 0.2 | 5.1 ± 0.3 | 3.9 ± 0.2 | 4.5 ± 0.4 | 8.40** | 1.21 |
Supramammillary body, medial | 5.1 ± 0.3 | 5.3 ± 0.2 | 3.7 ± 0.2 | 4.9 ± 0.4† | 10.41** | 5.82* |
Values are the means ± SEM for the number of mice indicated in parentheses. Results were analyzed by means of two-way ANOVA (age by genotype). There were no statistically significant interactions.
↵* p < 0.05; statistically significant main effect.
↵** p < 0.01; statistically significant main effect.
↵*** p < 0.001; statistically significant main effect.
↵† p < 0.05; statistically significantly different from age-matched WT; post hoc t test.
↵†† p < 0.01; statistically significantly different from age-matched WT; post hoc t test.