Summary of mRNA expression changes
| Schizophrenia | fBZ/fBZ | bdnf-/-Em | bdnf-/-Ad | |
|---|---|---|---|---|
| BDNF | ↓ 35%a | ↔ | ↓ 80% | ↓ 80% |
| TrkB | ↓ 23%b | ↓ 75% | ↑ 20% (p = 0.07) | ↔ |
| GAD67 | ↓ 26%b | ↓ 23% | ↔ | ↔ |
| PV | ↓ 30%c | ↓ 40% | ↔ | ↔ |
Percentages of changes from control subjects or from wild-type animals are presented with arrows indicating the direction of changes. Statistically significant changes (p < 0.05) are expressed in bold.
↵ a Average across 26 pairs in cohorts 1 and 2 (without pair 5 in cohort 2).
↵ b Average across 27 pairs in cohorts 1 and 2.
↵ c Average across 15 pairs in cohort 1 [bdnf-/-Em knock-out induced from late embryogenesis and bdnf-/-Ad knock-out induced in adulthood (12 weeks of age)].