Table 1.

ELISA hippocampal Aβ levels (pg/μg protein; means ± SE)

Assay Young Old p
PDAPP carbonate-soluble Aβ40 0.29 ± 0.03 2.95 ± 0.67 0.0002
PDAPP carbonate-insoluble Aβ40 1.21 ± 0.15 67.23 ± 15.56 0.00008
PDAPP carbonate-soluble Aβ42 0.38 ± 0.05 14.97 ± 3.17 0.00003
PDAPP carbonate-insoluble Aβ42 4.81 ± 0.65 667.89 ± 143.61 0.00003
WT carbonate-soluble Aβ40 0.07 ± 0.01 0.09 ± 0.01 NS
WT carbonate-insoluble Aβ40 0.11 ± 0.02 0.13 ± 0.02 NS
WT carbonate-soluble Aβ42 0.03 ± 0.003 0.04 ± 0.004 NS
WT carbonate-insoluble Aβ42 0.12 ± 0.01 0.16 ± 0.01 NS