Table 2.

Dendritic spine changes in the Tg2576 cortex

n (spines) Spine density (spines/μm) Spine length (μm) Mushroom (length, % total) Thin (length, % total) Stubby (length, % total)
Control 220 0.33 ± 0.12 1.25 ± 0.54 1.47 ± 0.60, 23.9 ± 9.7% 1.26 ± 0.49, 56.6 ± 15.8% 0.74 ± 0.21, 19.3 ± 13.5%
Tg2576 total 364 0.24 ± 0.08** 1.24 ± 0.64 1.51 ± 0.74, 26.3 ± 17.6% 1.25 ± 0.57, 56.9 ± 19.7% 0.69 ± 0.25, 21.8 ± 15.7%
Tg2576<15 μm from plaque 76 0.16 ± 0.07** 1.19 ± 0.58 1.33 ± 0.62, 24.0 ± 17.1% 1.16 ± 0.56, 55.0 ± 17.8% 0.65 ± 0.22, 25.3 ± 20.2%
Tg2576>15 μm from plaque 288 0.27 ± 0.07** 1.25 ± 0.66 1.58 ± 0.78 27.2 ± 18% 1.28 ± 0.57, 52.1 ± 20.6% 0.69 ± 0.25, 20.8 ± 13.6%
  • ** p<0.001 compared with control.