Table 4.

Summary of effects across modalities

Region Default Amyloid Metab Atrophy RSE
Medial temporal + +
Prefrontal + + −/+ −/+
Lateral temporal + + + +
Retrosplenial/precuneus + + + + +
Lateral parietal + + + + +a
  • Default, Presence in PET default network; Amyloid, presence in amyloid imaging measured by PIB; Metab, present as hypometabolism; Atrophy, presence in longitudinally estimated atrophy; RSE, presence in fMRI measured retrieval success effect; −, minimal or no effect; +, robust effect; −/+, minimal effect early in disease progression, robust effect later in progression.

  • a Lateralized (left > right).