Effect of growth factor overexpression on SC survival, recruitment, and differentiation in vivo
Series | Anti-human nuclei+ cells | GFP+ cells | PO+ structures | GFP+/PO+ structures | GFP-/PO+ structures |
---|---|---|---|---|---|
Lesion | 0 | 0 | 6 ± 2.7 | 0 | 6 ± 2.7 |
GFP | 254 ± 32 | 188 ± 47 | 48 ± 11 | 26 ± 7 | 22 ± 5.8 |
BDNF | 328 ± 49 | 264 ± 72 | 457 ± 82 | 31 ± 6 | 426 ± 71 |
NT-3 | 421 ± 27 | 368 ± 82 | 492 ± 91 | 127 ± 45 | 365 ± 82 |
Data represent the number of GFP+ cells and PO+ and GFP+/PO+ structures ± SEM per lesion in the four experimental series (n = 20 per series). Statistical differences were obtained between all groups for p < 0.001.