Table 1.

Latency (in seconds) to first press is not significantly altered by ibogaine or GDNF treatment a

Experiment Mean ± SEM Median (minimum, maximum)
Ethanol self-administration
Intraperitoneal vehicle 113.4 ± 48.3 67.4 (7.5, 439.4)
Intraperitoneal ibogaine 86.6 ± 17.8 86.6 (13.6, 191.4)
Ethanol relapse
Intraperitoneal vehicle 411.6 ± 139.4 427.5 (21.8,248.7)
Intraperitoneal ibogaine 163.0 ± 54.7 106.0 (27.6,461.9)
Ethanol self-administration
Intra-VTA ACSF 102.95 ± 19.23 98.78 (33.7,207.1)
Intra-VTA ibogaine (10 μm) 92.69 ± 22.14 63.71 (17.1,205.5)
Ethanol self-administration
Intra-VTA ACSF 176.43 ± 27.10 153.98 (27.6,295.6)
Intra-VTA GDNF 169.70 ± 30.23 145.75 (64.8,312.7)
  • a Wilcoxon matched-pairs test; all p > 0.05.