Table 2.

Open-field activity in C57BL/6J, 129/Sv, DBA/2J, and BALB/c mice given different doses of citalopram alone or in combination with TRP

Dose of citalopram (mg/kg) C57BL/6J 129/Sv
Veh 150.9 ± 6.3 (n = 8) 27.1 ± 6.8 (n = 8)
1.25 143.8 ± 8.5 (n = 8) ND
2.5 153.6 ± 10.4 (n = 8) 13.5 ± 6.2 (n = 8)
5.0 167.1 ± 7.9 (n = 8) 16.1 ± 10.6 (n = 8)
10.0 ND 11.3 ± 4.8 (n = 8)
Treatment DBA/2J BALB/c
Veh plus Veh 208.3 ± 12.3 (n = 8) 94.0 ± 10.3 (n = 9)
Veh plus Citalopram 232.6 ± 23.2 (n = 8) 160.3 ± 13.9* (n = 8)
TRP plus Veh 189.3 ± 14.6 (n = 8) 99.9 ± 4.7 (n = 8)
TRP plus Citalopram 182.9 ± 20.1 (n = 8) 131.5 ± 16.4 (n = 8)
  • Top, Effects of different doses of citalopram or vehicle (Veh) on open-field activity in C57BL/6J and 129/Sv mice. Bottom, Effects of TRP (300 mg/kg), citalopram (5 mg/kg), and vehicle alone or in combination on open-field activity in DBA/2J and BALB/c mice. Data are mean ± SEM. The number of mice is indicated in parentheses. *p<0.05 versus Veh plus Veh (Tukey-Kramer's test). ND, Not determined.