Table 1.

Number and phenotype of BrdU-positive cells

Y YR O OR
Cell number 613 (59)a 2355 (343)c 117 (50)a 656 (43)
Neuron (%) 49.9 (4.5)a 81.3 (3.3)c 9.5 (4.3)a 25.6 (7.5)
Astrocyte (%) 7.9 (2.5) 3.4 (1.3) 20.7 (5.5)b 19.1 (2.3)b
Other (%) 41.5 (3.7)a 14.7 (3.3)c 69.8 (6.9) 55.3 (5.8)
Volume (mm3) 0.39 (0.025) 0.39 (0.03) 0.42 (0.025) 0.40 (0.025)
  • Young and aged C57BL/6 mice were housed with or without a running wheel. All mice received BrdU injections (50 mg/kg) daily for the first 7 d. Survival and phenotype of BrdU-labeled cells as well as dentate gyrus volume were assessed 1 month after the last BrdU injection. The percentages of BrdU cells double labeled for NeuN (neurons), S100β (astrocytes), or neither marker are presented. Data are presented as means with SEM in parentheses.

  • a Significantly different from age-matched animals (p<0.05).

  • b Significantly different from Y, YR.

  • c Significantly different from all other groups.