Table 1.

Downregulated and upregulated genes in FB

Accession number	Gene name	Fold change	nAdv WT	nAdv −/−
U02096^a	Brain-type fatty acid binding protein (Fabp 7)	−7.0	1.58	0.23
M15901^a ^b	β-B3-2-crystallin (Cvekl et al., 1995)	−6.6	0.90	0.14
U47921^a ^b	αA (insert)-crystallin (Cvekl et al., 1995)	−5.1	2.27	0.44
L15556	Phospholipase C (β4)	−3.9	0.33	0.09
AF001898^a ^b	Aldehyde dehydrogenase (ALDH) (Suzuki et al., 2000)	−3.0	2.14	0.71
X13905	Ras-related rab 1B	−2.9	0.55	0.19
X54467	Preprocathepsin D	−2.6	0.70	0.27
X13412^a	Flk protein	−2.6	0.24	0.09
U06713	SM-20	−2.5	0.74	0.30
S49491^a	Proenkephalin	−2.4	0.69	0.29
U36482	Endoplasmic reticulum protein ERp29	−2.0	4.06	2.00
U59245^a	Menkes protein (MNK)	6.6	0.03	0.22
M85299	Sodium/hydrogen exchange protein-isoform 1 (NHE-1)	5.6	0.05	0.30
X60328	Cytosolic epoxide hydrolase	4.2	0.08	0.33
U75358	Myeloma protein kinase (PAK-2)	3.4	0.06	0.21
U34932	Fos-related antigen	3.3	0.09	0.29
AF022729^a ^b	HNK-1 sulfotransferase (Nagase et al., 2001)	2.8	0.17	0.47
S80345	von Hippel-Lindau tumor suppressor gene homolog (VHL)	2.6	0.10	0.26
L20823^a	Syntaxin 2	2.5	0.11	0.26
AF025671^a	Caspase 2 (Ich1)	2.4	0.36	0.84
AF035955^a	Kinesin-related protein 6 (KRP6)	2.4	0.20	0.52
M60617^a	CCAAT binding transcription factor-B subunit (CBF-A11)	2.4	0.15	0.35
AA875509^a	*cDNA clone similar to Mus musculus* Mdm2**	2.4	0.11	0.27
Z35138	Fibroblast growth factor receptor 2b	2.4	0.22	0.52
X61295	L1 retroposon, ORF2	2.4	0.70	1.71
AF061947	Cain	2.4	0.30	0.72
S74265	High-molecular-weight microtubule-associated protein 2 (HMW MAP2)	2.3	0.11	0.27
AF056324^a	Scaffold attachment factor B	2.3	0.19	0.45
S69329^b	Isl-1 (homeobox) (Stoykova et al., 2000)	2.3	0.17	0.40
D14013	Cyclin C	2.2	0.10	0.22
AF077354^a	Ischemia responsive 94 kDa protein (irp94)	2.2	0.45	0.98
AB008521	Dynein light intermediate chain 53/55	2.1	0.12	0.25
X70706^a	T-plastin	2.1	0.43	0.91
U51583	Zinc finger homeodomain enhancer-binding protein-1 (Zfhep-1)	2.1	0.15	0.33
X62951^a	pBUS19 with repetitive elements	2.1	0.51	1.04
U33472	Type 1 astrocyte and olfactory-limbic-associated protein AT1-46	2.1	0.37	0.80
M90514	DNA fragment homologous to Drosophila pecanex locus	2.1	0.11	0.23
U83666	Cell-cycle checkpoint protein kinase Bub1 (rbub1)	2.0	0.15	0.31
L01115^a	Adenylyl cyclase type VI	2.0	0.26	0.53

List of known genes downregulated and upregulated in an rSey²/rSey² rat FB sample based on the following criteria: a normalized average difference (nAdv) of>0.02 and a fold change of less than −2.0 or >2.0. The genes in italics and bold are those commonly downregulated and upregulated in rSey²/rSey² rat FB and HB samples, respectively.
↵ a Confirmed by quantitative PCR.
↵ b Reported in previous papers.