Modification of choroid plexus megalin activity in rodent models of cognitive impairment and its effect on Aβ levels, Hpf-tau, and cognition
| Model | Megalin | Aβ1-40* | Aβ1-42* | Hpf-tau* | Cognition** |
|---|---|---|---|---|---|
| APP/PS1 plus miniMeg | ↑ | = | = | ↓ | ↑ |
| Old rat plus miniMeg | ↑ | ↓ | = | ↓ | = |
| LID plus miniMeg | ↑ | ↓ | = | ↓ | ↑ |
| APP/PS1 plus siMeg | ↓ | ↑ | = | ↑ | ↓ |
Before treatment, all animal models had significantly high Aβ and Hpf-tau levels and deteriorated cognition. Arrows indicate significant changes in each parameter tested after modulation of megalin levels. =, Impairment remains; miniMeg, miniMegalin; siMeg, siMegalin.
*p < 0.05 versus respective control (HIV)-injected animals, by Student's t test; **p < 0.05, one-way ANOVA followed by Student's t test; n = 6-8 animals per experimental group.