Table 1.

Summary of the properties of the tonic and phasic (i.e., mIPSCs) GABAA receptor-mediated transmission in VB and nRT neurons of WT, β2N265S, and β2–/– mice

VB nRT
WT β2N265S β2-/-a WT β2N265S β2-/-
mIPSC amplitude (pA) 74 ± 4 82 ± 6 30 ± 3** 59 ± 3 68 ± 4 64 ± 6
mIPSC τW (ms) 4.1 ± 0.2 3.5 ± 0.1 ND 14.5 ± 1 12.1 ± 1 13.7 ± 1
mIPSC charge transfer (fC) 308 ± 20 317 ± 25 136 ± 20** 736 ± 39 713 ± 39 790 ± 63
mIPSC frequency (Hz) 52.6 ± 4 47.6 ± 8 20.8 ± 2** 12.4 ± 1 16.6 ± 3 14.6 ± 1
Phasic charge (fC/s) 16,201 15,090 2829 9126 11,836 11,534
Tonic current (pA) 62 ± 12 70 ± 13 28 ± 2* 5 ± 6 ND ND
Tonic charge (fC/s) 62,000 70,000 28,000 ND ND ND
Total charge (fC/s) 78,201 85,090 30,829 ND ND ND
  • * p < 0.05, **p < 0.001 versus wild type (n = 9-42 neurons). ND, Not determined.

  • a mIPSCs were evident only in 12 of 20 VB cells in β2-/- mice.