Table 1.

Classification of parameters

Known
Classes of parameters From Purkinje cells From other cells From reactions in test tubes From other molecular subtypes Unknown Total
Time constants (τ) 0 2 5 0 27 34
Dissociation constants (Kd) and Michaelis constants (Km) 6 6 9 5 3 29
Enzyme turnovers (Vmax) 0 3 5 1 3 12
Initial concentrations ([]) 7 7 3 1 3 21
Total 13 16 24 7 36 96
  • From Purkinje cells, Parameter values from measurements in cerebellar Purkinje cells; From other cells, parameter values from measurements in non-Purkinje cells, because data do not exist for Purkinje cells; From reaction in test tubes, parameter values from biochemical measurements of the reactions by purified molecules, because no data have been measured in cells; From other molecular subtypes, parameter values from biochemical measurements of purified similar subtypes, because data do not exist for the subtype measured. We used the parameter values for PLCβ1 instead of those for PLCβ4; Unknown, the remaining parameters, the values of which are not found in the literature.