Quipazine and robotic training independently improve stepping performance
| Baseline | Experiment II | Experiment III | |
|---|---|---|---|
| NT, -Q | RT, -Q | NT, +Q | |
| No. of steps | 16.0 | 31.6 ± 7.1c | 55.1 ± 13.0d |
| FFT FWHM (Hz)a | 1.20 | 0.81 ± 0.15c | 0.96 ± 0.12 |
| PCA (%)b | 35.0 | 76.4 ± 3.8c | 77.4 ± 3.9d |
NT, Nontrained; RT, robotically trained; +Q, treated with quipazine; -Q, not treated with quipazine. FWHM is of the dominant peak in the FFT spectrum between 0.4 and 1.4 Hz. SEM values are reported.
↵ a Lower values of FWHM correspond to improved step rhythm.
↵ b Higher values of PCA percentage correspond to improved step shape consistency, up to a practical maximum of ∼90%.
↵ c Based on all three measures of stepping ability, i.e., number of steps performed (p < 0.05), step rhythm (p < 0.05), and step shape consistency (p < 0.001), mice that received robotic training performed statistically better than nontrained, untreated mice.
↵ d Mice administered quipazine statistically improved the number of steps performed (p < 0.05) and step shape consistency (p < 0.001) compared with nontrained, untreated mice. Quipazine did not affect step rhythm.