Table 2.

Densitometric analysis of 2-DG accumulation in control, parkinsonian (MPTP), l-dopa nondyskinetic, and l-dopa dyskinetic animals

l-Dopa dyskinetic
MPTP l-Dopa nondyskinetic 30 min 60 min
Area Control (mean ± SEM) Mean ± SEM % Mean ± SEM % Mean % Mean ± SEM %
GPe-M 1.68 ± 0.11 1.96 ± 0.10* 16.67 1.75 ± 0.16 4.17 1.71 1.78 1.66 ± 0.09 −1.19
GPe-A 1.65 ± 0.10 1.87 ± 0.11* 13.34 1.67 ± 0.08 1.21 1.71 3.63 1.45 ± 0.08*†‡ −12.12
GPe-L 1.67 ± 0.11 1.95 ± 0.12* 16.77 1.79 ± 0.12 7.19 1.72 2.99 1.50 ± 0.13†‡ −10.18
STN-M 2.22 ± 0.14 1.83 ± 0.18* −17.57 2.24 ± 0.11 0.90 2.33 4.95 2.51 ± 0.11 13.06
STN-AL 2.52 ± 0.19 2.10 ± 0.15* −16.67 2.85 ± 0.12*† 13.09 2.67 5.95 2.91 ± 0.09*† 15.48
GPi 1.81 ± 0.14 2.14 ± 0.21* 18.23 2.24 ± 0.12* 23.76 2.22 22.65 2.51 ± 0.11*† 38.67
SNr 1.93 ± 0.18 2.15 ± 0.16 11.39 1.93 ± 0.16 0 1.97 2.07 2.24 ± 0.19 16.06
VA 1.82 ± 0.15 2.13 ± 0.08* 17.03 1.76 ± 0.07 −3.29 1.71 −6.04 1.67 ± 0.17 −8.24
VL 1.93 ± 0.16 2.40 ± 0.16* 24.35 1.97 ± 0.12 2.07 1.85 −4.1 1.80 ± 0.13 −6.74
MD 1.71 ± 0.07 1.79 ± 0.08 4.68 1.73 ± 0.17 1.17 1.69 −1.17 1.48 ± 0.11*†‡ −13.45
NStT 1.87 ± 0.08 1.83 ± 0.12 −2.14 1.77 ± 0.15 −5.35 1.81 −3.21 1.64 ± 0.10* −12.29
  • Data (mean ± SEM) are expressed in terms of tissue equivalent ratios of the amount of radioactivity in the considered structure to that in the white matter of the same section. % represents the mean difference with controls. Because a single individual is used 30 min after l-dopa administration, no SEM is given and no statistical analysis has been performed. *p<0.05, significant difference with control; p<0.05, significant difference with MPTP; p<0.05, significant difference with nondyskinetic.