Table 1.

Effects of ion channel blockers on excitability

DrugBaselineAfter drug
K+-channel blocker
    TEA (1 mm; n = 8)3.76 ± 0.314.71 ± 0.44*
    4-AP (3 mm; n = 9)3.54 ± 0.286.10 ± 0.29*
    Ba2+ (250 μm; n = 6)3.81 ± 0.254.13 ± 0.26
    Cs+ (10 mm; n = 6)3.72 ± 0.206.83 ± 0.23*
Ca2+-channel blocker
    Cd2+ (200 μm; n = 5)3.69 ± 0.243.73 ± 0.23
    Nimodipine/Ni2+ (10/50 μm; n = 6)3.85 ± 0.223.92 ± 0.22
Ca2+-activated K+-channel blocker
    UCL1684 (100 nm; n = 7)3.81 ± 0.233.94 ± 0.27
h-channel blocker
    ZD7288 (20 μm; n = 11)3.61 ± 0.266.47 ± 0.25*
  • * p < 0.05, paired t test.

  • Not significant.