Table 2.

Significant increases and decreases in regional blood flow in the patients during the scans defined for the condition stimulator on compared with the condition stimulator off

RegionBrodmann areasActivation in hypothalamic stimulation (n = 10)Deactivation in hypothalamic stimulation (n = 10)
Talairach coordinatesZ score of peak activationTalairach coordinatesZ score of peak deactivation
PrecuneusBA 74−4846Z= 4.08
Middle temporal gyrusBA 39−40−8628Z = 4.05
Hypothalamusa14−8−8Z = 3.67
Thalamusa4−108Z = 3.88
Inferior temporal gyrusBA 2024−14−36Z = 3.83
Anterior cingulate cortexaBA 24−1024−14Z = 3.83
Posterior cingulate cortexBA 3020−5420Z = 3.71
Primary somatosensory cortexBA 2−54−1824Z = 3.59
Trigeminal nucleus14−28−28Z = 3.48
Cerebellum/vermis10−54−16Z = 4.24
Anterior insula3816−10Z = 3.56−3828−6Z = 3.48
Middle temporal gyrusBA 21−50−5010Z = 4.10
Inferior temporal gyrusBA 38−468−48
3410−44Z = 4.06
Z = 3.44
Superior frontal gyrusBA 10−185818Z = 3.76
Posterior cingulate cortexBA 2416−1042Z = 3.73
  • The activation and deactivation are tabulated in terms of the activated brain regions and their Brodmann areas, the x, y, z coordinates to the standardized anatomical space, and refer to the relative distance to the anterior commissure–posterior commissure line (joining the anterior and posterior commissures), which is situated at 0 mm. Each location is the peak within a cluster (defined as the voxel with the highest Z score; p < 0.05). L, Left; r, right; BA, Brodmann area.

  • aSmall volume correction.