Intracellular properties of Up states in vivo
| Parameters | |||||||
|---|---|---|---|---|---|---|---|
| RP mean (mV) | RP SD (mV) | G mean (nS) | G max (nS) | G max time (ms) | Ge mean (nS) | Gi mean (nS) | |
| Voltage clamp: 0–500 ms from start of Up state | |||||||
| Group (n = 8) | −37.17 | 6.54 | 21.14 | 25.99 | 105.87 | 9.24 | 11.41 |
| SD | 7.97 | 3.30 | 10.62 | 23.19 | 37.16 | 4.13 | 8.42 |
| Range | −49.14 | 0.95 | 9.37 | 13.08 | 54 | 6.68 | 4.00 |
| −24.53 | 7.96 | 49.98 | 66.47 | 152 | 17.34 | 33.70 | |
| RP mean (mV) | RP SD (mV) | G mean (nS) | G max (nS) | G max time (ms) | Ge mean (nS) | Gi mean (nS) | |
| Voltage clamp: −400 to 0 ms before end of Up state | |||||||
| Group (n = 8) | −30.54 | 4.04 | 10.90 | 20.39 | −331.62 | 5.55 | 4.25 |
| SD | 14.20 | 3.55 | 3.88 | 12.94 | 43.07 | 2.18 | 1.88 |
| Range | −44.91 | 1.20 | 4.45 | 8.06 | −399 | 3.12 | 0.75 |
| −9.82 | 11.71 | 19.86 | 45.04 | −265 | 11.24 | 7.57 | |
| UP to DN (mV) | SD UP (mV) | SD DN (mV) | UP Dur (s) | DN Dur (s) | DN to UP (s) | UP to DN (s) | |
| Current clamp | |||||||
| RS neurons (n = 9) | 13.19 | 2.13 | 0.79 | 1.58 | 0.26 | 0.13 | 0.17 |
| SD | 4.64 | 0.61 | 0.29 | 0.51 | 0.17 | 0.04 | 0.03 |
| Range | 9.30 | 1.55 | 0.25 | 0.76 | 0.16 | 0.07 | 0.13 |
| 18.59 | 3.44 | 1.16 | 2.48 | 0.41 | 0.17 | 0.21 | |
| FS neurons (n = 4) | 14.41 | 2.79 | 0.60 | 1.13 | 0.37 | 0.10 | 0.12 |
| SD | 5.13 | 0.71 | 0.17 | 0.25 | 0.22 | 0.06 | 0.03 |
| Range | 9.85 | 2.14 | 0.25 | 0.88 | 0.16 | 0.05 | 0.08 |
| 20.02 | 3.54 | 0.85 | 1.39 | 0.60 | 0.17 | 0.16 | |
RP, Reverse potential; G, total conductance; Ge, excitatory conductance; Gi, inhibitory conductance; DN, Down state.