Genotype | Wild type | Knock-out | Wild type | Knock-out |
---|---|---|---|---|
Lesion | − | − | + | + |
Regulated genes >1.5 or <0.66 | 940 | 930 | 757 | 682 |
Regulated genes >2 or <0.5 | 365 | 314 | 309 | 271 |
Signaling | 47/12.9% | 34/11.1% | 35/11.3% | 28/10.3% |
Cytoskeleton | 14/3.8% | 11/3.5% | 14/4.5% | 13/4.8% |
Guidance | 5/1.4% | 9/2.9% | 4/1.3% | 2/0.7% |
Extracellular matrix/cell adhesion | 20/5.5% | 20/6.4% | 12/3.9% | 12/4.4% |
Growth machinery | 13/3.6% | 15/4.8% | 12/3.9% | 11/4.1% |
Synapse | 7/1.9% | 5/1.6% | 4/1.3% | 3/1.1% |
Immune response | 26/7.1% | 24/7.6% | 45/14.6% | 32/11.8% |
Myelin proteins | 2/0.6% | 2/0.6% | 2/0.6% | 2/0.7% |
Channels | 2/0.5% | 4/1.3% | 12/3.9% | 14/5.2% |
Transport related | 35/9.6% | 30/9.6% | 5/1.6% | 3/1.1% |
Cancer related | 3/0.8% | 4/1.3% | 2/0.6% | 2/0.7% |
Blood related | 4/1.1% | 1/0.3% | 6/1.9% | 3/1.1% |
Cell cycle/growth | 27/7.4% | 8/2.5% | 9/2.9% | 10/3.7% |
DNA/RNA related | 56/15.3% | 37/11.8% | 31/10.0% | 34/12.5% |
Transcription factors | 10/2.7% | 17/5.4% | 10/3.2% | 8/3.0% |
Protein related | 27/7.4% | 25/8 % | 21/6.8% | 18/6.6% |
Organelle related | 1/0.3% | 4/1.3% | 3/1.0% | 3/1.1% |
Metabolism | 29/7.9% | 29/9.2% | 23/7.4% | 24/8.9% |
Others | 37/10.1% | 34/10.8% | 60/19.4% | 49/18.1% |
Differentially regulated genes (Sv129 compared with BL/6) were sorted in different categories, and the number of regulated genes and percentage are shown for every condition.