Cytoskeleton | ||
ARP1 actin-related protein 1 homolog A | Actr1a | 0.34 |
ARP1 actin-related protein 1 homolog A (yeast) | Actr1a | 0.14 |
Axonemal dynein heavy chain 7 | 0.45 | |
Beaded filament structural protein 2, phakinin | Bfsp2 | 0.41 |
Capping protein (actin filament), gelsolin-like | Capg | 2.39 |
Centrin 4 | LOC207175 | 0.48 |
CLIP-associating protein 1 | Clasp1 | 3.14 |
CLIP-associating protein 2 | Clasp2 | 3.85 |
Cysteine-rich hydrophobic domain 1 | Chic1 | 0.31 |
Ectodermal-neural cortex 1 | Enc1 | 3.18 |
Formin 2 | Fmn2 | 0.47 |
Gelsolin | Gsn | 0.14 |
Gelsolin | Gsn | 0.15 |
Kinesin 7 | 0.47 | |
Kinesin family member 11 | Kif11 | 2.68 |
LIM and SH3 protein 1 | Lasp1 | 2.12 |
LIM homeobox protein 2 | Lhx2 | 6.25 |
Myosin IB | Myo1b | 2.31 |
Myosin VIIa | Myo7a | 0.44 |
Spectrin α 1 | Spna1 | 2.08 |
Spectrin α 1 | Spna1 | 7.10 |
Tau tubulin kinase 1 | Ttbk1 | 2.27 |
T-complex testis expressed 1 | Tctex1 | 2.05 |
T-complex testis expressed 1 | Tctex1 | 2.72 |
T-complex-associated testis expressed 1 | Tcte1 | 2.04 |
Tropomodulin 2 | Tmod2 | 0.30 |
Troponin I, skeletal, slow 1 | Tnni1 | 0.07 |
Villin 2 | Vil2 | 2.77 |
ECM/cell adhesion | ||
Cadherin 1 | Cdh1 | 3.63 |
Cadherin 4 | Cdh4 | 0.42 |
Calnexin | Canx | 0.40 |
Catenin α 1 | Catna1 | 2.48 |
Cell adhesion molecule with homology to L1CAM | Chl1 | 0.32 |
Collagen XII α 1 (Col12a1) | Cox7a2 | 0.45 |
Dentin matrix protein 1 | Dmp1 | 0.38 |
Dentin matrix protein 1 | Dmp1 | 0.48 |
EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | Emr4 | 3.19 |
Hyaluronic acid binding protein 4 | Habp4 | 2.58 |
Integrin α 4 | Itga4 | 3.50 |
Integrin α 6 | Itga6 | 2.38 |
Kin of IRRE-like 3 (Drosophila) | Kirrel3 | 2.41 |
Kin of IRRE-like 3 (Drosophila) | Kirrel3 | 2.01 |
Lectin, galactose binding, soluble 3 | Lgals3 | 0.49 |
Lectin, galactoside-binding, soluble 3, binding protein | Ppicap | 0.40 |
Neogenin | Neo1 | 2.01 |
Ninjurin 2 | Ninj2 | 0.30 |
Periostin, osteoblast-specific factor | AI747096 | 3.64 |
Poliovirus receptor-related 3 | Pvrl3 | 2.77 |
Procollagen, type I, α 2 | Col1a2 | 3.47 |
Procollagen, type IV, α 1 | Col4a1 | 2.05 |
Procollagen, type V, α 2 | Col5a2 | 3.35 |
Procollagen, type XIV, α 1 | Col14a1 | 3.54 |
Proteoglycan 4 (megakaryocyte-stimulating factor, articular superficial zone protein) | Prg4 | 2.63 |
Protocadherin 10 | Pcdh10 | 2.77 |
Protocadherin 18 | Pcdh18 | 0.45 |
Protocadherin 8 | Pcdh8 | 2.44 |
Protocadherin β 16 | Pcdhb16 | 2.24 |
Spondin 1 (f-spondin) extracellular matrix protein | Spon1 | 0.41 |
UBX domain containing 2 | 1300013G12Rik | 0.28 |
UBX domain containing 2 | 1300013G12Rik | 0.42 |
Growth machinery | ||
Bone morphogenetic protein 1 | Bmp1 | 0.25 |
Bone morphogenetic protein 4 | Bmp4 | 2.66 |
CAP, adenylate cyclase-associated protein 1 | Cap1 | 12.95 |
Doublecortin | Dcx | 0.40 |
Fibroblast growth factor 1 | Fgf1 | 3.43 |
Fibroblast growth factor 7 | Fgf7 | 3.59 |
Growth arrest-specific 5 | Gas5 | 0.43 |
Heat shock protein 1-like | Hspa1l | 0.15 |
Histocompatibility 2, class II antigen A, β 1 | H2-Ab1 | 2.69 |
Histocompatibility 2, class II antigen E, β | H2-Eb1 | 0.34 |
Histocompatibility 28 | H28 | 19.07 |
Hypoxia upregulated 1 | Cab140 | 2.92 |
IL2-inducible T-cell kinase | Itk | 7.88 |
Ig heavy chain (J558 family) | Igh-VJ558 | 0.49 |
Ig κ chain variable 8 (V8) | Igk-V8 | 2.87 |
Ig superfamily, member 4 | A830029E02Rik | 2.35 |
Interferon activated gene 202B | Ifi202b | 101.53 |
Interferon activated gene 202B | Ifi202b | 10.22 |
Interferon activated gene 205 | Ifi205 | 0.18 |
Interferon-dependent positive-acting transcription factor 3γ | Isgf3g | 0.47 |
Interferon γ -induced GTPase | Igtp | 0.46 |
Interferon γ -inducible protein 30 | Ifi30 | 2.04 |
Interferon inducible protein 1 | Ifi1 | 0.41 |
Interferon γ -inducible protein 16 | Ifi16 | 0.38 |
Interferon-induced protein plus tetratrico repeats 1 | Ifit1 | 0.31 |
Interferon-induced protein plus tetratrico repeats3 | Ifit3 | 0.35 |
Interferon-stimulated protein | G1p2 | 0.30 |
Interleukin 2 receptor, γ chain | Il2rg | 0.47 |
Lymphocyte-activation gene 3 | Lag3 | 0.35 |
Macrophage scavenger receptor 2 | Msr2 | 0.17 |
Mouse IgE-binding factor mRNA | 0.27 | |
Myeloid cell leukemia sequence 1 | Mcl1 | 2.10 |
Paired Ig-like type 2 receptor β | Pilrb | 3.12 |
Pentaxin-related gene | Ptx3 | 0.38 |
Programmed cell death 4 | Pdcd4 | 3.19 |
Programmed cell death 6-interacting protein | Pdcd6ip | 0.46 |
Serine (or cysteine) proteinase inhibitor, clade A, 1b | Serpina1b | 86.03 |
Serine (or cysteine) proteinase inhibitor, clade A, 3N | Serpina3n | 3.30 |
TAP binding protein | Tapbp | 0.44 |
T-cell-specific GTPase | Tgtp | 0.31 |
TRAF-binding protein | Trabid | 2.07 |
Tumor necrosis factor receptor superfamily, 11b | Tnfrsf11b | 2.94 |
Myelin proteins | ||
Galactosylceramidase | Galc | 0.12 |
Galactosylceramidase | Galc | 0.10 |
Myelin basic protein | Mbp | 2.80 |
Myelin basic protein | Mbp | 7.56 |
Synapse formation/maintenance | ||
Caveolin, caveolae protein | Cav | 2.54 |
Cellubrevin | Vamp3 | 0.45 |
Pam, highwire, rpm 1 | Phr1 | 2.60 |
Rab6 interacting protein 2 | Rab6ip2 | 0.26 |
Receptor-associated protein of the synapse | Rapsn | 4.09 |
SNAP-associated protein | Ilf2 | 3.09 |
Synaptic vesicle glycoprotein 2c | Sv2c | 21.13 |
Synaptopodin | Synpo | 0.48 |
Synaptotagmin 1 | Syt1 | 2.17 |
Synaptotagmin 2 | Syt2 | 0.35 |
Syntaxin 11 | Stx11 | 2.67 |
Signaling | ||
3-Monooxygenase/tryptophan 5-monooxygenase activation protein, γ | Ywhag | 0.44 |
Activin receptor IIA | Acvr2 | 2.71 |
Adenomatosis polyposis coli | Apc | 2.21 |
Adenylate cyclase 7 | Adcy7 | 2.73 |
Adenylate kinase 3α -like | Ak3l | 0.27 |
Ankyrin repeat domain 17 | Ankrd17 | 2.13 |
Ankyrin repeat domain 17 | Ankrd17 | 2.33 |
Calbindin-28K | Calb1 | 2.32 |
Calcium/calmodulin-dependent kinase II, δ | Camk2d | 0.23 |
Growth factor receptor bound protein 2-associated protein 3 | Gab3 | 3.51 |
Insulin-induced gene 2 | Insig2 | 2.42 |
Insulin-like growth factor binding protein 3 | Igfbp3 | 2.98 |
Insulin-like growth factor binding protein 3 | Igfbp3 | 2.92 |
MAD homolog 4 (Drosophila) | Madh4 | 2.81 |
Myocilin | Myoc | 0.14 |
Myocilin | Myoc | 0.05 |
Platelet-derived growth factor, D polypeptide | Pdgfd | 0.28 |
Platelet-derived growth factor, D polypeptide | Pdgfd | 0.36 |
Suprabasin | Sbsn | 0.43 |
Suprabasin | Sbsn | 0.35 |
Teratocarcinoma-derived growth factor | Tdgf1 | 0.24 |
Timeless homolog (Drosophila) | Timeless | 2.25 |
Timeless interacting protein | 1110005A05Ri | 2.72 |
Timeless interacting protein | 1110005A05Ri | 5.98 |
Transforming growth factor β 1-induced transcript 4 | Tgfb1i4 | 15.92 |
Transforming growth factor, β induced | Tgfbi | 2.88 |
Zinc finger protein 91 | Zfp91 | 2.51 |
Guidance | ||
Deleted in colorectal carcinoma | Dcc | 2.90 |
Eph receptor A3 | Epha3 | 2.64 |
Eph receptor B3 | Ephb3 | 2.32 |
Neuron navigator 1 | Nav1 | 0.48 |
Sema domain 6D | Sema6d | 7.56 |
Sema domain 6D | Sema6d | 2.37 |
Sema domain 5A | Sema5a | 2.08 |
SemaF cytoplasmic domain-associated protein 3 | 1110020C07Ri | 2.48 |
Slit homolog 2 (Drosophila) | Slit2 | 2.43 |
Immune response | ||
Baculoviral IAP repeat-containing 6 | Birc6 | 0.40 |
Bcl2-antagonist/killer 1 | Bak1 | 2.84 |
Bcl2-like 2 | Bcl2l2 | 2.42 |
Beclin 1 (myosin-like Bcl2-interacting protein) | Becn1 | 3.08 |
β 2 microglobulin | B2m | 0.39 |
C1q and tumor necrosis factor-related protein 4 | 0710001E10Rik | 14.28 |
Caspase 8-associated protein 2 | Casp8ap2 | 3.12 |
Caspase recruitment domain family, member 10 | Card10 | 2.58 |
Cathepsin E | Ctse | 7.52 |
CD5 antigen-like | Cd5l | 0.03 |
CD59a antigen | Cd59a | 2.72 |
CD59a antigen | Cd59a | 2.32 |
CD84 antigen | Cd84 | 0.29 |
Chemokine (C-C motif) ligand 12 | Ccl12 | 0.30 |
Chemokine (C-C motif) ligand 2 | Ccl2 | 0.48 |
Chemokine (C-C motif) ligand 25 | Ccl25 | 3.67 |
Chemokine (C-C) receptor-like 1 | Ccrl1 | 3.55 |
Chemokine (C-X-C motif) ligand 10 | Cxcl10 | 0.27 |
Chemokine (C-X-C motif) ligand 9 | Cxcl9 | 0.12 |
Colony stimulating factor 2 receptor | Csf2rb2 | 7.67 |
Complement component 1, q subcomponent, β polypeptide | C1qb | 0.40 |
Complement component 1, q subcomponent, γ polypeptide | C1qg | 0.46 |
Complement component 1, q subcomponent, γ polypeptide | C1qg | 0.43 |
Complement component 1, r subcomponent | C1r | 0.49 |
Complement protein C1q B-chain | C1qb | 0.39 |
Constant region of Ig μ | Igh-6 | 0.41 |
Cystatin F (leukocystatin) | Cst7 | 0.44 |
Cytotoxic granule-associated RNA binding protein 1 | Tia1 | 0.04 |
EF hand domain containing 2 | D4Wsu27e | 0.38 |
EF hand domain containing 2 | D4Wsu27e | 0.35 |
Fibrinogen-like protein 2 | Fgl2 | 2.13 |
Friend virus susceptibility 1 | Fv1 | 3.28 |
Friend virus susceptibility 1 | Fv1 | 2.98 |
Heat shock 70 kDa protein 8 | 0.45 | |
Heat shock protein 1-like | Hspa1l | 0.09 |
Calmodulin-like 4 | Calml4 | 2.04 |
Diacylglycerol kinase ζ | Dgkz | 2.08 |
Diaphanous homolog 2 (Drosophila) | Diap2 | 2.66 |
Doublecortin plus calcium/calmodulin-dependent kinase-like 1 | Dcamkl1 | 0.46 |
Doublecortin plus calcium/calmodulin-dependent kinase-like 1 | Dcamkl1 | 2.69 |
Down syndrome critical region gene 1-like 1 | Dscr1l1 | 0.30 |
Fibroblast activation protein | Fap | 2.16 |
Formyl peptide receptor-like 1 | Fprl1 | 2.66 |
Frizzled-related protein | Frzb | 2.17 |
G-protein-coupled receptor 23 | Gpr23 | 2.63 |
G-protein-coupled receptor 27 | Gpr27 | 2.47 |
G-protein-coupled receptor 84 | Gpr84 | 0.45 |
G-protein-coupled receptor, family C, group 5, B | Gprc5b | 4.96 |
Guanine nucleotide binding protein, γ 4 subtype | Gng4 | 0.31 |
Guanine nucleotide binding protein, β 1 | Gnb1 | 3.45 |
GDP dissociation inhibitor 3 | Gdi3 | 2.02 |
Guanylate nucleotide binding protein 1 | Gbp1 | 47.62 |
Guanylate nucleotide binding protein 2 | Gbp2 | 0.33 |
Guanylate nucleotide binding protein 3 | Gbp3 | 0.39 |
Guanylate nucleotide binding protein 3 | Gbp3 | 2.90 |
Inositol polyphosphate-4-phosphatase, type I | Inpp4a | 3.09 |
Jagged 1 | Jag1 | 5.42 |
Microtubule associated serine/threonine kinase 2 | Mtssk | 2.14 |
Mitogen-activated protein kinase 8 | Mapk8 | 3.54 |
Mitogen-activated protein kinase kinase kinase 12 | Map3k12 | 3.19 |
Mitogen-activated protein kinase kinase kinase 6 | Map3k6 | 0.46 |
Patched homolog | Ptch | 0.26 |
Periaxin | Prx | 2.77 |
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150 | Pik3r4 | 0.42 |
Phosphatidylinositol 3-kinase, C2 domain-containing, α polypeptide | Pik3c2a | 8.33 |
Phosphatidylinositol 4-kinase, catalytic, β | Pik4cb | 5.45 |
Phosphatidylinositol glycan, class F | Pigf | 2.01 |
Phosphodiesterase 7A | Pde7a | 2.28 |
Phosphoinositide-3-kinase adaptor protein 1 | Pik3ap1 | 2.74 |
Phospholipase C, β 4 | Plcb4 | 2.06 |
Protein kinase C, α | Prkca | 5.00 |
Protein kinase inhibitor, γ | Pkig | 0.45 |
Protein kinase, AMP-activated, α 2 catalytic | Prkaa2 | 2.03 |
Protein phosphatase 1, regulatory (inhibitor) 1A | Ppp1r1a | 2.10 |
Protein phosphatase 1, regulatory (inhibitor) 1A | Ppp1r1a | 2.74 |
Protein phosphatase 1, regulatory (inhibitor) 7 | Ppp1r7 | 2.02 |
Protein tyrosine phosphatase 4a2 | Ptp4a2 | 2.24 |
Protein tyrosine phosphatase, nonreceptor type 12 | Ptpn12 | 2.32 |
Protein tyrosine phosphatase, receptor type, C | Ptprc | 2.20 |
RAB2, member Ras oncogene family | Rab2 | 2.58 |
RAB3C, member Ras oncogene family | Rab3c | 0.19 |
Ras association (RalGDS/AF-6) domain family 2 | Rassf2 | 0.40 |
Ras association (RalGDS/AF-6) domain family 2 | Rassf2 | 0.48 |
Ras association (RalGDS/AF-6) domain family 5 | Rassf5 | 0.22 |
Regulator of G-protein signaling 2 | Rgs2 | 2.17 |
Regulator of G-protein signaling 4 | Rgs4 | 2.04 |
Rhophilin, Rho GTPase binding protein 2 | Rhpn2 | 0.48 |
Rhophilin, Rho GTPase binding protein 2 | Rhpn2 | 0.50 |
Secreted Frizzled-related sequence protein 1 | Sfrp1 | 0.40 |
Secreted Frizzled-related sequence protein1 | Sfrp1 | 0.33 |
Septin 3 (Sept3), mRNA | 2.02 | |
Serine/threonine kinase 25 (yeast) | Stk25 | 0.49 |
Serine/threonine kinase 25 (yeast) | Stk25 | 0.27 |
Sorting nexin 4 | Snx4 | 2.03 |
T-complex expressed gene 1 | Tce1 | 0.26 |
Transducer of ErbB2, 2 | Tob2 | 2.54 |
Transducin-like enhancer of split 1 | Tle1 | 2.10 |
Tripartite motif protein 12 | Trim12 | 0.05 |
Tripartite motif protein 30 | Trim30 | 0.35 |
Tripartite motif protein 30-like | LOC209387 | 0.16 |
Tripartite motif protein 30-like | LOC209387 | 0.27 |
Tripartite motif protein 34 | Trim34 | 0.12 |
Tripartite motif protein 34 | Trim34 | 0.24 |
Tubby-like protein 4 | Tulp4 | 3.22 |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ | Ywhaz | 4.86 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ | Ywhaz | 5.52 |
Unc-51-like kinase 2 (Caenorhabditis elegans) | Ulk2 | 4.74 |
Wingless-related MMTV integration site 7B | Wnt7b | 0.47 |
Differentially regulated genes (Sv129 compared with BL/6) belonging to the categories cytoskeleton, neurite growth and guidance, ECM/cell adhesion, immune response, myelin, synaptic function, and signaling, which show fold changes >2 or <0.5 (regulated genes 1 week after lesion in bold). A list of all of the regulated genes (also categories metabolism, RNA and DNA related, protein synthesis, proteolysis, channels/transporters/carriers, cell cycle, stress related, endocytosis, and transport) with fold changes >1.5 or <0.66 are shown in the supplemental table (available at www.jneurosci.org as supplemental material). CLIP, Cytoplasmic linker protein; EGF, epidermal growth factor; Eph, ephrin; IAP, inhibitor of apoptosis; IRRE, irregular chiasm; LIM, Lin-11/Isl-1/Mec-3; PDZ, postsynaptic density 95/Discs large/zona occludens-1; REC8, recombination 8; Sema, semaphorin; SH3, Src homology 3; UBX, ubiquitin-like.