Table 3.

Brain areas activated during the comparison of fMRI signal change differences (after treatment > before treatment) between both placebo and control sides

fMRI signal change difference Area (Brodmann area) Z score Number of voxels in cluster Peak coordinate (x, y, z)
Within mask
    P > C Right anterior insula 3.21 30 46, 20, -4
    C > P Left M1 (4) 4.00 170 -18, -18, 60
Outside mask
    P > C Right inferior parietal lobule (40) 4.19 240 60, -36, 52
Left superior frontal gyrus (6) 3.57 47 -20, 20, 66
Right inferior frontal gyrus/anterior insula (47) 3.50 105 48, 22, -2
Left inferior parietal lobule (40) 3.38 164 -56, -54, 46
Left middle frontal gyrus (10) 3.33 74 -46, 50, 12
Right middle frontal gyrus (10) 3.05 31 40, 58, 2
Right middle frontal gyrus (46, 9) 3.02 36 52, 38, 26
Left inferior frontal gyrus (44) 2.98 87 -54, 12, 28
Bilateral rACC (32) 2.96 33 2, 44, 10
Right inferior frontal gyrus (46) 2.86 27 48, 40, 8
Right supramarginal gyrus (40) 2.81 29 60, -58, 32
    C > P Nothing above threshold
  • The threshold is set to voxel-wise p < 0.005 with 20 continuous voxels for predefined ROIs and voxel-wise p < 0.001 uncorrected with 20 contiguous voxels and cluster p < 0.05 corrected for other regions. Peak coordinates refer to the MNI atlas. P, Placebo; C, control.