Table 1.

Loss of Flk1 does not affect the differentiation of neurons and glia from the progeny of either p-NSCs derived from Flk1−/− ES cells or d-NSCs derived from E14.5 NesCre;Flk1−/− conditional knock-out mice

MAP2+ neuron (n)GFAP+ astrocyte (n)
p-NSC Flk1+/+2.5 ± 0.6% (4)17.4 ± 5.9% (4)
p-NSC Flk1−/−2.2 ± 0.8% (4)18.7 ± 6.0% (4)
d-NSC Flk1+/+3.8 ± 1.1% (5)43.6 ± 5.7% (5)
d-NSC Flk1−/−3.4 ± 0.9% (4)38.3 ± 7.6% (4)
  • The proportions of microtubule-associated protein 2 (MAP2)+ and GFAP+ cells were calculated from total cells.