β2*-nAChR availability in nonsmokers versus smokers
| Region | Nonsmokers (n = 16), mean ± SD | Smokers (n = 16), mean ± SD | % Difference smokers vs nonsmokers | F statistic | p value |
|---|---|---|---|---|---|
| Thalamus | 48.1 ± 8.4 | 52.3 ± 8.3 | 8.7% | 2.03 | 0.1651 |
| Striatum | 24.5 ± 3.8 | 31.1 ± 5.0 | 26.9% | 17.43 | 0.0002* |
| Parietal cortex | 17.9 ± 2.6 | 22.9 ± 4.4 | 27.9% | 15.23 | 0.0005* |
| Frontal cortex | 19.9 ± 2.8 | 25.1 ± 4.9 | 26.1% | 13.34 | 0.0010* |
| Anterior cingulate | 18.8 ± 2.7 | 25.5 ± 4.5 | 35.6% | 26.34 | 0.00002* |
| Temporal cortex | 20.6 ± 3.4 | 26.2 ± 4.0 | 27.2% | 18.32 | 0.0002* |
| Occipital cortex | 18.6 ± 2.8 | 25.3 ± 4.7 | 36.0% | 23.75 | 0.00003* |
| Cerebellum | 23.0 ± 4.5 | 28.8 ± 4.8 | 25.2% | 12.56 | 0.0013* |
β2*-nAChR availability is reported as VT′ = regional [123I]5-IA activity/total plasma [123I]5-IA activity.
↵*p values <0.00625 are significant after Bonferroni's correction.