Table 1.

Quantification of midline errors in EphB/ephrinB mutant mice

GenotypeNumber of embryosTotal cohorts% Cohorts displaying midline errorsa
Wild type26941 (1%)
ephrinB3+/−2811510 (9%)*
ephrinB3−/−3212813 (10%)*
ephrinB3+/lacz12430 (0%)
ephrinB3lacz10341 (3%)
EphB2+/−B3−/−16665 (8%)*
EphB2−/−B3−/−19764 (5%)
EphB1−/−B2+/−B3−/−20788 (10%)*
EphB1−/−B2−/−B3−/−176810 (15%)*
  • * p < 0.05; χ2 approximation.

  • a Midline errors were defined as aberrant axon projections that were observed either while crossing the floor plate or within the vicinity of the midline (see Results and Materials and Methods for details).